Prevalence of persistent and latent viruses in untreated patients infected with HIV‐1 from Ghana, West Africa
Identifieur interne : 000A71 ( Main/Exploration ); précédent : 000A70; suivant : 000A72Prevalence of persistent and latent viruses in untreated patients infected with HIV‐1 from Ghana, West Africa
Auteurs : Lara Isobel Compston [Royaume-Uni] ; Chengyao Li [République populaire de Chine] ; Francis Sarkodie [Ghana] ; Shirley Owusu-Ofori [Ghana] ; Ohene Opare-Sem [Ghana] ; Jean-Pierre Allain [Royaume-Uni]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2009-11.
Descripteurs français
- KwdFr :
- Adolescent, Adulte d'âge moyen, Cellules sanguines (virologie), Comorbidité, Cytomegalovirus (isolement et purification), Ghana (épidémiologie), Herpèsvirus humain de type 3 (isolement et purification), Herpèsvirus humain de type 4 (isolement et purification), Herpèsvirus humain de type 8 (isolement et purification), Humains, Infections à VIH (), Jeune adulte, Latence virale, Maladies virales (virologie), Maladies virales (épidémiologie), Parvovirus humain B19 (isolement et purification), Plasma sanguin (virologie), Prévalence, Réaction de polymérisation en chaîne (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification), Virus GB-C (isolement et purification), Virus de l'hépatite B (isolement et purification), Virémie.
- MESH :
- isolement et purification : Cytomegalovirus, Herpèsvirus humain de type 3, Herpèsvirus humain de type 4, Herpèsvirus humain de type 8, Parvovirus humain B19, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Virus GB-C, Virus de l'hépatite B.
- virologie : Cellules sanguines, Maladies virales, Plasma sanguin.
- épidémiologie : Ghana, Maladies virales.
- Adolescent, Adulte d'âge moyen, Comorbidité, Humains, Infections à VIH, Jeune adulte, Latence virale, Prévalence, Réaction de polymérisation en chaîne, Virémie.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adolescent, Antibody prevalence, Antibody response, Assay, Asymptomatic, Background prevalence, Baseline odds, Black boxes, Blood Cells (virology), Blood donor, Blood donor controls, Blood donor group, Blood donors, Bold donor controls, Bone marrow, Cambridge blood centre, Cell count, Cellular, Cellular fraction, Cellular samples, Clin, Clin microbiol, Clinical implications, Clinical stage, Cohort, Comorbidity, Compston, Control group, Cytomegalovirus (isolation & purification), Detectable viraemia, Donor, Exact test, GB virus C (isolation & purification), Ghana (epidemiology), Ghanaian blood donors, Grant sponsor, Gray boxes, HIV Infections (complications), HIV-1 (isolation & purification), Healthy blood donors, Hepatitis, Hepatitis B virus (isolation & purification), Herpesvirus, Herpesvirus 3, Human (isolation & purification), Herpesvirus 4, Human (isolation & purification), Herpesvirus 8, Human (isolation & purification), Human herpesvirus, Human virus, Humans, Immune, Immune restoration disease, Important role, Infection, Komfo anokye teaching hospital, Middle Aged, Natural history, Occult, Occult hepatitis, Odds ratio, Odds ratios, Opportunistic infection, Opportunistic infections, Overall prevalence, Parvovirus, Parvovirus B19, Human (isolation & purification), Peripheral blood, Persistent viruses, Plasma (virology), Plasma fraction, Plasma samples, Plasma viraemia, Polymerase Chain Reaction (methods), Positive cohorts, Positive groups, Potential marker, Potential reactivation, Predictor, Prevalence, Prospective study, Reactivation, Risk factors, Roche diagnostics, Seroprevalence, Sexual transmission, Single virus, Symptomatic group, Symptomatic patients, Target virus, Total number, Transmission routes, Untreated patients, Useful guide, Viraemia, Viraemia prevalence, Viral, Viral load, Viral markers, Viral reactivation, Viral replication, Viremia, Virol, Virus, Virus Diseases (epidemiology), Virus Diseases (virology), Virus Latency, Virus infection, Virus load, Whole blood, Young Adult.
- MESH :
- geographic , epidemiology : Ghana.
- complications : HIV Infections.
- epidemiology : Virus Diseases.
- isolation & purification : Cytomegalovirus, GB virus C, HIV-1, Hepatitis B virus, Herpesvirus 3, Human, Herpesvirus 4, Human, Herpesvirus 8, Human, Parvovirus B19, Human.
- methods : Polymerase Chain Reaction.
- virology : Blood Cells, Plasma, Virus Diseases.
- Teeft :
- Adolescent, Antibody prevalence, Antibody response, Assay, Asymptomatic, Background prevalence, Baseline odds, Black boxes, Blood donor, Blood donor controls, Blood donor group, Blood donors, Bold donor controls, Bone marrow, Cambridge blood centre, Cell count, Cellular, Cellular fraction, Cellular samples, Clin, Clin microbiol, Clinical implications, Clinical stage, Cohort, Comorbidity, Compston, Control group, Detectable viraemia, Donor, Exact test, Ghanaian blood donors, Grant sponsor, Gray boxes, Healthy blood donors, Hepatitis, Herpesvirus, Human herpesvirus, Human virus, Humans, Immune, Immune restoration disease, Important role, Infection, Komfo anokye teaching hospital, Middle Aged, Natural history, Occult, Occult hepatitis, Odds ratio, Odds ratios, Opportunistic infection, Opportunistic infections, Overall prevalence, Parvovirus, Peripheral blood, Persistent viruses, Plasma fraction, Plasma samples, Plasma viraemia, Positive cohorts, Positive groups, Potential marker, Potential reactivation, Predictor, Prevalence, Prospective study, Reactivation, Risk factors, Roche diagnostics, Seroprevalence, Sexual transmission, Single virus, Symptomatic group, Symptomatic patients, Target virus, Total number, Transmission routes, Untreated patients, Useful guide, Viraemia, Viraemia prevalence, Viral, Viral load, Viral markers, Viral reactivation, Viral replication, Viremia, Virol, Virus, Virus Latency, Virus infection, Virus load, Whole blood, Young Adult.
Abstract
Only limited epidemiological data, pertaining to the prevalence of common persistent viruses has been reported in Ghana. This study was conducted to determine the prevalence of persistent viruses in individuals with untreated HIV‐1 infection and uninfected blood donors. Paired plasma and cellular samples from HIV‐negative blood donors, asymptomatic HIV and symptomatic/AIDS cohorts were screened by multiplex PCR then qPCR for parvovirus B19 (B19V), hepatitis B virus (HBV), GB virus‐C (GBV‐C), cytomegalovirus (CMV), Epstein–Barr virus (EBV), human herpesvirus‐8 (HHV‐8) and varicella‐zoster virus (VZV). IgG antibodies specific to each target virus were tested to determine exposure rates. No evidence of viraemia was found for B19V and VZV in any group. Prevalence of GBV‐C plasma viraemia was significantly higher in asymptomatic and symptomatic HIV infection (16.7%) and (16.2%) than in blood donors (4%) P < 0.005. Occult HBV infection was significantly more frequent in symptomatic HIV infection (10.9%) compared to asymptomatic HIV (3.6%) and blood donors (1.6%) P < 0.005. Although there was a high background of EBV viraemia in cellular fractions of blood donors (8.3%), it was significantly higher in asymptomatic (44.6%) and symptomatic HIV (14.6%) P < 0.0001. For CMV, the significantly increased prevalence of viraemia was only observed in the plasma fraction of the symptomatic HIV‐1/AIDS patients (7.6%) compared to asymptomatic individuals (1.8%) and blood donors (0.8%) P ≤ 0.001. The background seroprevalence in blood donors was high for B19V (≥64%), HBV (≥70%), CMV and EBV (≥90%) and was significantly increased in HIV infections for HBV, CMV, VZV (symptomatic HIV), and HHV‐8 (asymptomatic and symptomatic HIV). J. Med. Virol. 81:1860–1868, 2009. © 2009 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.21614
Affiliations:
- Ghana, Royaume-Uni, République populaire de Chine
- Angleterre, Angleterre de l'Est, Guangdong
- Cambridge, Jiangmen
- Université de Cambridge
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type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name><affiliation wicri:level="1"><country xml:lang="fr">Ghana</country><wicri:regionArea>Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Owusu Fori, Shirley" sort="Owusu Fori, Shirley" uniqKey="Owusu Fori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name><affiliation wicri:level="1"><country xml:lang="fr">Ghana</country><wicri:regionArea>Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Opare Em, Ohene" sort="Opare Em, Ohene" uniqKey="Opare Em O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name><affiliation 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CB2 2PT</wicri:regionArea><wicri:noRegion>Cambridge CB2 2PT</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">81</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1860">1860</biblScope><biblScope unit="page" to="1868">1868</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-11">2009-11</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Antibody prevalence</term><term>Antibody response</term><term>Assay</term><term>Asymptomatic</term><term>Background prevalence</term><term>Baseline odds</term><term>Black boxes</term><term>Blood Cells (virology)</term><term>Blood donor</term><term>Blood donor controls</term><term>Blood donor group</term><term>Blood donors</term><term>Bold donor controls</term><term>Bone marrow</term><term>Cambridge blood centre</term><term>Cell count</term><term>Cellular</term><term>Cellular fraction</term><term>Cellular samples</term><term>Clin</term><term>Clin microbiol</term><term>Clinical implications</term><term>Clinical stage</term><term>Cohort</term><term>Comorbidity</term><term>Compston</term><term>Control group</term><term>Cytomegalovirus (isolation & purification)</term><term>Detectable viraemia</term><term>Donor</term><term>Exact test</term><term>GB virus C (isolation & purification)</term><term>Ghana (epidemiology)</term><term>Ghanaian blood donors</term><term>Grant sponsor</term><term>Gray boxes</term><term>HIV Infections (complications)</term><term>HIV-1 (isolation & purification)</term><term>Healthy blood donors</term><term>Hepatitis</term><term>Hepatitis B virus (isolation & purification)</term><term>Herpesvirus</term><term>Herpesvirus 3, Human (isolation & purification)</term><term>Herpesvirus 4, Human (isolation & purification)</term><term>Herpesvirus 8, Human (isolation & purification)</term><term>Human herpesvirus</term><term>Human virus</term><term>Humans</term><term>Immune</term><term>Immune restoration disease</term><term>Important role</term><term>Infection</term><term>Komfo anokye teaching hospital</term><term>Middle Aged</term><term>Natural history</term><term>Occult</term><term>Occult hepatitis</term><term>Odds ratio</term><term>Odds ratios</term><term>Opportunistic infection</term><term>Opportunistic infections</term><term>Overall prevalence</term><term>Parvovirus</term><term>Parvovirus B19, Human (isolation & purification)</term><term>Peripheral blood</term><term>Persistent viruses</term><term>Plasma (virology)</term><term>Plasma fraction</term><term>Plasma samples</term><term>Plasma viraemia</term><term>Polymerase Chain Reaction (methods)</term><term>Positive cohorts</term><term>Positive groups</term><term>Potential marker</term><term>Potential reactivation</term><term>Predictor</term><term>Prevalence</term><term>Prospective study</term><term>Reactivation</term><term>Risk factors</term><term>Roche diagnostics</term><term>Seroprevalence</term><term>Sexual transmission</term><term>Single virus</term><term>Symptomatic group</term><term>Symptomatic patients</term><term>Target virus</term><term>Total number</term><term>Transmission routes</term><term>Untreated patients</term><term>Useful guide</term><term>Viraemia</term><term>Viraemia prevalence</term><term>Viral</term><term>Viral load</term><term>Viral markers</term><term>Viral reactivation</term><term>Viral replication</term><term>Viremia</term><term>Virol</term><term>Virus</term><term>Virus Diseases (epidemiology)</term><term>Virus Diseases (virology)</term><term>Virus Latency</term><term>Virus infection</term><term>Virus load</term><term>Whole blood</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte d'âge moyen</term><term>Cellules sanguines (virologie)</term><term>Comorbidité</term><term>Cytomegalovirus (isolement et purification)</term><term>Ghana (épidémiologie)</term><term>Herpèsvirus humain de type 3 (isolement et purification)</term><term>Herpèsvirus humain de type 4 (isolement et purification)</term><term>Herpèsvirus humain de type 8 (isolement et purification)</term><term>Humains</term><term>Infections à VIH ()</term><term>Jeune adulte</term><term>Latence virale</term><term>Maladies virales (virologie)</term><term>Maladies virales (épidémiologie)</term><term>Parvovirus humain B19 (isolement et purification)</term><term>Plasma sanguin (virologie)</term><term>Prévalence</term><term>Réaction de polymérisation en chaîne ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification)</term><term>Virus GB-C (isolement et purification)</term><term>Virus de l'hépatite B (isolement et purification)</term><term>Virémie</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Cytomegalovirus</term><term>GB virus C</term><term>HIV-1</term><term>Hepatitis B virus</term><term>Herpesvirus 3, Human</term><term>Herpesvirus 4, Human</term><term>Herpesvirus 8, Human</term><term>Parvovirus B19, Human</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Cytomegalovirus</term><term>Herpèsvirus humain de type 3</term><term>Herpèsvirus humain de type 4</term><term>Herpèsvirus humain de type 8</term><term>Parvovirus humain B19</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Virus GB-C</term><term>Virus de l'hépatite B</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules sanguines</term><term>Maladies virales</term><term>Plasma sanguin</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Blood Cells</term><term>Plasma</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ghana</term><term>Maladies virales</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adolescent</term><term>Antibody prevalence</term><term>Antibody response</term><term>Assay</term><term>Asymptomatic</term><term>Background prevalence</term><term>Baseline odds</term><term>Black boxes</term><term>Blood donor</term><term>Blood donor controls</term><term>Blood donor group</term><term>Blood donors</term><term>Bold donor controls</term><term>Bone marrow</term><term>Cambridge blood centre</term><term>Cell count</term><term>Cellular</term><term>Cellular fraction</term><term>Cellular samples</term><term>Clin</term><term>Clin microbiol</term><term>Clinical implications</term><term>Clinical stage</term><term>Cohort</term><term>Comorbidity</term><term>Compston</term><term>Control group</term><term>Detectable viraemia</term><term>Donor</term><term>Exact test</term><term>Ghanaian blood donors</term><term>Grant sponsor</term><term>Gray boxes</term><term>Healthy blood donors</term><term>Hepatitis</term><term>Herpesvirus</term><term>Human herpesvirus</term><term>Human virus</term><term>Humans</term><term>Immune</term><term>Immune restoration disease</term><term>Important role</term><term>Infection</term><term>Komfo anokye teaching hospital</term><term>Middle Aged</term><term>Natural history</term><term>Occult</term><term>Occult hepatitis</term><term>Odds ratio</term><term>Odds ratios</term><term>Opportunistic infection</term><term>Opportunistic infections</term><term>Overall prevalence</term><term>Parvovirus</term><term>Peripheral blood</term><term>Persistent viruses</term><term>Plasma fraction</term><term>Plasma samples</term><term>Plasma viraemia</term><term>Positive cohorts</term><term>Positive groups</term><term>Potential marker</term><term>Potential reactivation</term><term>Predictor</term><term>Prevalence</term><term>Prospective study</term><term>Reactivation</term><term>Risk factors</term><term>Roche diagnostics</term><term>Seroprevalence</term><term>Sexual transmission</term><term>Single virus</term><term>Symptomatic group</term><term>Symptomatic patients</term><term>Target virus</term><term>Total number</term><term>Transmission routes</term><term>Untreated patients</term><term>Useful guide</term><term>Viraemia</term><term>Viraemia prevalence</term><term>Viral</term><term>Viral load</term><term>Viral markers</term><term>Viral reactivation</term><term>Viral replication</term><term>Viremia</term><term>Virol</term><term>Virus</term><term>Virus Latency</term><term>Virus infection</term><term>Virus load</term><term>Whole blood</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte d'âge moyen</term><term>Comorbidité</term><term>Humains</term><term>Infections à VIH</term><term>Jeune adulte</term><term>Latence virale</term><term>Prévalence</term><term>Réaction de polymérisation en chaîne</term><term>Virémie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Only limited epidemiological data, pertaining to the prevalence of common persistent viruses has been reported in Ghana. This study was conducted to determine the prevalence of persistent viruses in individuals with untreated HIV‐1 infection and uninfected blood donors. Paired plasma and cellular samples from HIV‐negative blood donors, asymptomatic HIV and symptomatic/AIDS cohorts were screened by multiplex PCR then qPCR for parvovirus B19 (B19V), hepatitis B virus (HBV), GB virus‐C (GBV‐C), cytomegalovirus (CMV), Epstein–Barr virus (EBV), human herpesvirus‐8 (HHV‐8) and varicella‐zoster virus (VZV). IgG antibodies specific to each target virus were tested to determine exposure rates. No evidence of viraemia was found for B19V and VZV in any group. Prevalence of GBV‐C plasma viraemia was significantly higher in asymptomatic and symptomatic HIV infection (16.7%) and (16.2%) than in blood donors (4%) P < 0.005. Occult HBV infection was significantly more frequent in symptomatic HIV infection (10.9%) compared to asymptomatic HIV (3.6%) and blood donors (1.6%) P < 0.005. Although there was a high background of EBV viraemia in cellular fractions of blood donors (8.3%), it was significantly higher in asymptomatic (44.6%) and symptomatic HIV (14.6%) P < 0.0001. For CMV, the significantly increased prevalence of viraemia was only observed in the plasma fraction of the symptomatic HIV‐1/AIDS patients (7.6%) compared to asymptomatic individuals (1.8%) and blood donors (0.8%) P ≤ 0.001. The background seroprevalence in blood donors was high for B19V (≥64%), HBV (≥70%), CMV and EBV (≥90%) and was significantly increased in HIV infections for HBV, CMV, VZV (symptomatic HIV), and HHV‐8 (asymptomatic and symptomatic HIV). J. Med. Virol. 81:1860–1868, 2009. © 2009 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Ghana</li><li>Royaume-Uni</li><li>République populaire de Chine</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Guangdong</li></region><settlement><li>Cambridge</li><li>Jiangmen</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Compston, Lara Isobel" sort="Compston, Lara Isobel" uniqKey="Compston L" first="Lara Isobel" last="Compston">Lara Isobel Compston</name></region><name sortKey="Allain, Jean Ierre" sort="Allain, Jean Ierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name><name sortKey="Allain, Jean Ierre" sort="Allain, Jean Ierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name></country><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Li, Chengyao" sort="Li, Chengyao" uniqKey="Li C" first="Chengyao" last="Li">Chengyao Li</name></region></country><country name="Ghana"><noRegion><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name></noRegion><name sortKey="Opare Em, Ohene" sort="Opare Em, Ohene" uniqKey="Opare Em O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name><name sortKey="Owusu Fori, Shirley" sort="Owusu Fori, Shirley" uniqKey="Owusu Fori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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